Lung Restriction From Childhood Is Associated With Obstructive Sleep Apnoea in Middle-Age.

Chamara V Senaratna; Dinh S Bui; Jennifer L Perret; Caroline J Lodge; Adrian J Lowe; Michael J Abramson; Bircan Erbas; Paul Thomas; Robert Adams; David P Johns; Yaoyao Qian; George Washko; E Haydn Walters; Garun S Hamilton; Shyamali C Dharmage

Journal article

Lung Restriction From Childhood Is Associated With Obstructive Sleep Apnoea in Middle-Age.

Chamara V Senaratna, Dinh S Bui, Jennifer L Perret, Caroline J Lodge, Adrian J Lowe, Michael J Abramson, Bircan Erbas, Paul Thomas, Robert Adams, David P Johns, Yaoyao Qian, George Washko, E Haydn Walters, Garun S Hamilton, Shyamali C Dharmage

Respirology | Published : 2026

DOI: 10.1002/resp.70326

Abstract

BACKGROUND AND OBJECTIVE: Whether lifetime lung function trajectories and spirometry patterns are associated with Obstructive Sleep Apnoea (OSA) is unknown. We aimed to investigate this association to widen the understanding of OSA pathophysiology. METHODS: We previously identified six FEV1/FVC (forced expiratory volume in the first second/forced vital capacity) and five FVC trajectories within a population-based prospective cohort (n = 2422) using spirometry assessed at ages 7, 13, 18, 43, 50, and 53 years. These trajectories were combined into four lifetime spirometry patterns: restrictive-only, obstructive-only, mixed, and reference (normal), which were our exposure variables. Outcomes we..

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